Performance of liver stiffness measurements obtained with FibroScan is affected by glucose metabolism in patients with nonalcoholic fatty liver disease

Abstract Background The performance of liver stiffness measurements (LSMs) obtained using FibroScan can be affected by several factors, and cut-off values are different for fibrosis caused various aetiologies. study aims to evaluate the diagnostic accuracy LSM in nonalcoholic fatty disease (NAFLD) patients with abnormal glucose metabolism investigate whether value would metabolic indicators. Methods involved 91 NAFLD who underwent biopsy. was evaluated receiver operator characteristic (ROC) curves, biopsy results taken as gold standard. Multivariate linear regression subgroup analysis were performed determine correlated Results areas under ROC curves (AUROCs) detecting stage ?1, 2, 3 4 0.793 (95% confidence interval [CI]: 0.695–0.871), 0.764 CI: 0.663–0.846), 0.837 0.744–0.906) 0.902 0.822–0.955), 6.3, 7.6, 8.3 13.8 kPa, respectively. demonstrated that haemoglobin A1c (HbA1c, ? = 0.205, P 0.026) alanine aminotransferase (ALT, 0.192, 0.047) independently associated after adjustment stage, ballooning inflammation grade from Subgroup slightly higher HbA1c ?7% than those < 7% body mass index (BMI) ?30 kg/m 2 BMI 30 . Conclusions valuable evaluation metabolism. is recommended severe fibrosis, especially exclude advanced fibrosis. Glucose state may affect values.